Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility.
Sci Rep
; 12(1): 21635, 2022 12 14.
Article
en En
| MEDLINE
| ID: mdl-36517633
ABSTRACT
Based on the pharmaceutical potentials of coumarins, which have antitumor activity, we synthesized new coumarin derivatives and evaluated their biological activities. The new coumarin derivatives were chemically synthesized from 4-hydroxycoumarin, and their structures were confirmed by nuclear magnetic resonance data. Ten of the synthesized compounds were investigated for antimetastatic activity against lung carcinoma cells. Several of the tested compounds showed good to mild inhibitory effects on lung cancer cell motility. There were no cytotoxic effects related to the use of these compounds. 4-Hydroxycoumarin derivatives, 4h and 4i, elicited the significant inhibitory effect on lung cancer cell motility by suppressing expression of the epithelial-mesenchymal transition markers N-cadherin, Snail, and Twist.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
4-Hidroxicumarinas
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Neoplasias Pulmonares
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Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article