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Microtubule-Stabilizing 1,2,4-Triazolo[1,5-a]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal New Structure-Activity Insights.
Alle, Thibault; Varricchio, Carmine; Yao, Yuemang; Lucero, Bobby; Nzou, Goodwell; Demuro, Stefania; Muench, Megan; Vuong, Khoa D; Oukoloff, Killian; Cornec, Anne-Sophie; Francisco, Karol R; Caffrey, Conor R; Lee, Virginia M-Y; Smith, Amos B; Brancale, Andrea; Brunden, Kurt R; Ballatore, Carlo.
  • Alle T; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
  • Varricchio C; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, U.K.
  • Yao Y; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce St., Philadelphia, Pennsylvania 19104, United States.
  • Lucero B; Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
  • Nzou G; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce St., Philadelphia, Pennsylvania 19104, United States.
  • Demuro S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
  • Muench M; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce St., Philadelphia, Pennsylvania 19104, United States.
  • Vuong KD; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
  • Oukoloff K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
  • Cornec AS; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, 231 South 34th St., Philadelphia, Pennsylvania 19104-6323, United States.
  • Francisco KR; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
  • Caffrey CR; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
  • Lee VM; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce St., Philadelphia, Pennsylvania 19104, United States.
  • Smith AB; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, 231 South 34th St., Philadelphia, Pennsylvania 19104-6323, United States.
  • Brancale A; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF103NB, U.K.
  • Brunden KR; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce St., Philadelphia, Pennsylvania 19104, United States.
  • Ballatore C; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
J Med Chem ; 66(1): 435-459, 2023 01 12.
Article en En | MEDLINE | ID: mdl-36534051
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Enfermedad de Alzheimer Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Enfermedad de Alzheimer Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article