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Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.
Khor, Chiea Chuen; Winter, Stefan; Sutiman, Natalia; Mürdter, Thomas E; Chen, Sylvia; Lim, Joanne Siok Liu; Li, Zheng; Li, Jingmei; Sim, Kar Seng; Ganchev, Boian; Eccles, Diana; Eccles, Bryony; Tapper, William; Zgheib, Nathalie K; Tfayli, Arafat; Ng, Raymond Chee Hui; Yap, Yoon Sim; Lim, Elaine; Wong, Mabel; Wong, Nan Soon; Ang, Peter Cher Siang; Dent, Rebecca; Tremmel, Roman; Klein, Kathrin; Schaeffeler, Elke; Zhou, Yitian; Lauschke, Volker M; Eichelbaum, Michel; Schwab, Matthias; Brauch, Hiltrud B; Chowbay, Balram; Schroth, Werner.
  • Khor CC; Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
  • Winter S; Singapore Eye Research Institute, Singapore, Singapore.
  • Sutiman N; Clinical Pharmacology, SingHealth, Singapore, Singapore.
  • Mürdter TE; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
  • Chen S; University Tübingen, Tübingen, Germany.
  • Lim JSL; Clinical Pharmacology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore.
  • Li Z; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
  • Li J; University Tübingen, Tübingen, Germany.
  • Sim KS; Clinical Pharmacology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore.
  • Ganchev B; Clinical Pharmacology Laboratory, Division of Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore.
  • Eccles D; Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
  • Eccles B; Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
  • Tapper W; Division of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
  • Zgheib NK; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
  • Tfayli A; University Tübingen, Tübingen, Germany.
  • Ng RCH; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.
  • Yap YS; University Hospital Southampton National Health Service Foundation Trust, Southampton, UK.
  • Lim E; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.
  • Wong M; University Hospital Southampton National Health Service Foundation Trust, Southampton, UK.
  • Wong NS; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.
  • Ang PCS; University Hospital Southampton National Health Service Foundation Trust, Southampton, UK.
  • Dent R; Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Tremmel R; Hematology-Oncology Division, Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Klein K; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore.
  • Schaeffeler E; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore.
  • Zhou Y; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore.
  • Lauschke VM; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore.
  • Eichelbaum M; OncoCare Cancer Centre, Mount Elizabeth Novena Medical Centre, Singapore, Singapore.
  • Schwab M; OncoCare Cancer Centre, Mount Elizabeth Novena Medical Centre, Singapore, Singapore.
  • Brauch HB; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore.
  • Chowbay B; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
  • Schroth W; University Tübingen, Tübingen, Germany.
Clin Pharmacol Ther ; 113(3): 712-723, 2023 03.
Article en En | MEDLINE | ID: mdl-36629403
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Citocromo P-450 CYP2D6 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Citocromo P-450 CYP2D6 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Año: 2023 Tipo del documento: Article