The interactions of amyloid ß aggregates with phospholipid membranes and the implications for neurodegeneration.
Biochem Soc Trans
; 51(1): 147-159, 2023 02 27.
Article
en En
| MEDLINE
| ID: mdl-36629697
ABSTRACT
Misfolding, aggregation and accumulation of Amyloid-ß peptides (Aß) in neuronal tissue and extracellular matrix are hallmark features of Alzheimer's disease (AD) pathology. Soluble Aß oligomers are involved in neuronal toxicity by interacting with the lipid membrane, compromising its integrity, and affecting the function of receptors. These facts indicate that the interaction between Aß oligomers and cell membranes may be one of the central molecular level factors responsible for the onset of neurodegeneration. The present review provides a structural understanding of Aß neurotoxicity via membrane interactions and contributes to understanding early events in Alzheimer's disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos beta-Amiloides
/
Enfermedad de Alzheimer
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article