Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis.
Stem Cell Res
; 67: 103018, 2023 03.
Article
en En
| MEDLINE
| ID: mdl-36630840
ABSTRACT
Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated human induced pluripotent stem cells (hiPSCs) from four COVID-19 patients, all characterized by increased levels of high-sensitivity Troponin I (hsTnI) during the infection acute phase, who developed (n = 2) or not (n = 2) severe myocarditis, as COVID-19 complication. The established hiPSCs were characterized for pluripotency and genomic stability, and constitute a useful resource for studying the mechanisms underlying the variability in COVID-19 severe cardiac manifestations.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Madre Pluripotentes Inducidas
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COVID-19
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Miocarditis
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article