Polyneurines A-H, iboga alkaloids from Tabernaemontana polyneura.
Phytochemistry
; 208: 113587, 2023 Apr.
Article
en En
| MEDLINE
| ID: mdl-36646163
ABSTRACT
Eight undescribed iboga alkaloids, polyneurines A-H, were isolated from the bark of Tabernaemontana polyneura. The structures of these alkaloids were established by interpretation of the MS and NMR data, while the configurations were determined using GIAO NMR calculations and DP4+ probability analysis, TDDFT-ECD method, or X-ray diffraction analysis. Polyneurine A possesses a γ-lactone unit embedded within the iboga skeleton, while polyneurines D and E incorporate a formylmethyl moiety at C-3 of the iboga skeleton. Biosynthetic pathways towards the formation of polyneurines A, C, D, and E were proposed.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tabernaemontana
/
Alcaloides
Idioma:
En
Año:
2023
Tipo del documento:
Article