Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain and Modulation via Direct Interactions with DNA Abasic Sites: Understanding the Mechanisms Involved in Castration-Resistant Prostate Cancer.

Xu, Shangze; Kondal, Matthew D; Ahmad, Ayaz; Zhu, Ruidi; Fan, Lanyu; Zaborniak, Piotr; Madden, Katrina S; de Souza, João V; Bronowska, Agnieszka K

Xu, Shangze; Kondal, Matthew D; Ahmad, Ayaz; Zhu, Ruidi; Fan, Lanyu; Zaborniak, Piotr; Madden, Katrina S; de Souza, João V; Bronowska, Agnieszka K.

Xu S; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Kondal MD; Newcastle University Centre for Cancer, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Ahmad A; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Zhu R; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Fan L; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Zaborniak P; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Madden KS; School of Engineering, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
de Souza JV; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.
Bronowska AK; Chemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK.

Int J Mol Sci ; 24(2)2023 Jan 09.

Article en En | MEDLINE | ID: mdl-36674785

Asunto(s)

Neoplasias de la Próstata Resistentes a la Castración; Receptores Androgénicos; Masculino; Humanos; Receptores Androgénicos/metabolismo; Neoplasias de la Próstata Resistentes a la Castración/genética; Neoplasias de la Próstata Resistentes a la Castración/metabolismo; Andrógenos/metabolismo; Dominios Proteicos; ADN/genética

Palabras clave

DNA-protein adducts; DNA-protein interactions; androgen receptor; castration-resistant prostate cancer; dimerisation; molecular dynamics simulations; protein-protein interactions

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores Androgénicos / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Año: 2023 Tipo del documento: Article

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