Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia.

Saghaug, Christina S; Gamlem, Astrid L; Hauge, Kirsti B; Vahokoski, Juha; Klotz, Christian; Aebischer, Toni; Langeland, Nina; Hanevik, Kurt

Saghaug, Christina S; Gamlem, Astrid L; Hauge, Kirsti B; Vahokoski, Juha; Klotz, Christian; Aebischer, Toni; Langeland, Nina; Hanevik, Kurt.

Saghaug CS; Department of Clinical Science, University of Bergen, Bergen, Norway; Norwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address: christina.saghaug@uib.no.
Gamlem AL; Department of Clinical Science, University of Bergen, Bergen, Norway.
Hauge KB; Department of Clinical Science, University of Bergen, Bergen, Norway.
Vahokoski J; Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Klotz C; Department of Infectious Diseases, Unit 16 Mycotic and Parasitic Agents and Mycobacteria, Robert Koch-Institute, Berlin, Germany.
Aebischer T; Department of Infectious Diseases, Unit 16 Mycotic and Parasitic Agents and Mycobacteria, Robert Koch-Institute, Berlin, Germany.
Langeland N; Department of Clinical Science, University of Bergen, Bergen, Norway; Norwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Hanevik K; Department of Clinical Science, University of Bergen, Bergen, Norway; Norwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Int J Parasitol Drugs Drug Resist ; 21: 51-60, 2023 04.

Article en En | MEDLINE | ID: mdl-36682328

Asunto(s)

Antiprotozoarios; Giardia lamblia; Metronidazol/farmacología; Antiprotozoarios/farmacología; Ferredoxinas/genética; Ferredoxinas/metabolismo; Piruvato-Sintasa/genética; Piruvato-Sintasa/metabolismo; Giardia; Nitrorreductasas/genética; Nitrorreductasas/metabolismo; Variación Genética

Palabras clave

Allele; Genetic diversity; Metronidazole; Nitroreductase; Nonsense mutation; Pyruvate ferredoxin oxidoreductase; Resistance; SNP; SNV

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Giardia lamblia / Antiprotozoarios Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Giardia lamblia / Antiprotozoarios Idioma: En Año: 2023 Tipo del documento: Article