Facile synthesis of 2-[(3-aminopropyl)thio]adenosine 5'-diphosphate: a key intermediate for the synthesis of molecular probes of adenosine 5'-diphosphate function.
J Med Chem
; 30(11): 2013-6, 1987 Nov.
Article
en En
| MEDLINE
| ID: mdl-3669009
ABSTRACT
Adenosine 5'-diphosphate (ADP) and, uniquely, its C-2 derivatized analogues are able to induce platelet activation. We here report the synthesis of 2-[(3-aminopropyl)thio]-ADP from ADP itself via 1,N6-etheno-ADP. 2-[(3-Aminopropyl)thio]-ADP induced platelet aggregation with a potency about one-seventh that of ADP itself and should prove a useful intermediate in the synthesis of other probes of platelet function.
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Banco de datos:
MEDLINE
Asunto principal:
Tionucleótidos
/
Adenosina Difosfato
/
Adenosina Trifosfato
/
Agregación Plaquetaria
Límite:
Humans
Idioma:
En
Año:
1987
Tipo del documento:
Article