Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-&#954;B signaling pathway.

Lv, Shuquan; Zhang, Zhongyong; Su, Xiuhai; Li, Wendong; Wang, Xiaoyun; Pan, Baochao; Li, Hanzhou; Zhang, Hui; Wang, Yuansong

Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.

Lv, Shuquan; Zhang, Zhongyong; Su, Xiuhai; Li, Wendong; Wang, Xiaoyun; Pan, Baochao; Li, Hanzhou; Zhang, Hui; Wang, Yuansong.

Lv S; Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.
Zhang Z; Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.
Su X; Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.
Li W; Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.
Wang X; Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.
Pan B; Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, China.
Li H; Graduate School, Chengde Medical University, Chengde, China.
Zhang H; Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, China.
Wang Y; Department of Endocrinology, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese Medicine, Cangzhou, China.

Front Endocrinol (Lausanne) ; 13: 1106875, 2022.

Article en En | MEDLINE | ID: mdl-36743916

Asunto(s)

Medicamentos Herbarios Chinos; Endotoxemia; Microbioma Gastrointestinal; Enfermedad del Hígado Graso no Alcohólico; Animales; Ratones; Colina; Dieta; Microbioma Gastrointestinal/genética; Inflamación/tratamiento farmacológico; Inflamación/metabolismo; Lipopolisacáridos; Metionina/metabolismo; FN-kappa B/metabolismo; Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico; Enfermedad del Hígado Graso no Alcohólico/etiología; Enfermedad del Hígado Graso no Alcohólico/metabolismo; Racemetionina; ARN Ribosómico 16S; Transducción de Señal; Uniones Estrechas/metabolismo; Receptor Toll-Like 4/metabolismo; Medicamentos Herbarios Chinos/uso terapéutico

Palabras clave

Qingrequzhuo capsule; TLR4/NF-κB signaling pathway; gut microbiota; methionine and choline deficient diet; nonalcoholic steatohepatitis

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Endotoxemia / Enfermedad del Hígado Graso no Alcohólico / Microbioma Gastrointestinal Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article

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