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Increasing Pancreatic Cancer Incidence in Young Women in the United States: A Population-Based Time-Trend Analysis, 2001-2018.
Abboud, Yazan; Samaan, Jamil S; Oh, Janice; Jiang, Yi; Randhawa, Navkiran; Lew, Daniel; Ghaith, Jenan; Pala, Pranav; Leyson, ChristineAnn; Watson, Rabindra; Liu, Quin; Park, Kenneth; Paski, Shirley; Osipov, Arsen; Larson, Brent K; Hendifar, Andrew; Atkins, Katelyn; Nissen, Nicholas N; Li, Debiao; Pandol, Stephen J; Lo, Simon K; Gaddam, Srinivas.
  • Abboud Y; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Samaan JS; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
  • Oh J; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
  • Jiang Y; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Randhawa N; Department of Internal Medicine, Franciscan Health, Olympia Fields, Illinois.
  • Lew D; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Ghaith J; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Pala P; Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, India.
  • Leyson C; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Watson R; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Liu Q; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Park K; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Paski S; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Osipov A; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Larson BK; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
  • Hendifar A; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Atkins K; Cedars-Sinai Medical Center, Department of Radiation Oncology, Los Angeles, California.
  • Nissen NN; Department of Pancreatic and Biliary Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
  • Li D; Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  • Pandol SJ; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Lo SK; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California.
  • Gaddam S; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: srinivas.gaddam@cshs.org.
Gastroenterology ; 164(6): 978-989.e6, 2023 05.
Article en En | MEDLINE | ID: mdl-36775072
ABSTRACT
BACKGROUND &

AIMS:

Previous studies have shown an increasing incidence of pancreatic cancer (PC), especially in younger women; however, this has not been externally validated. In addition, there are limited data about contributing factors to this trend. We report age and sex-specific time-trend analysis of PC age-adjusted incidence rates (aIRs) using the National Program of Cancer Registries database without Surveillance Epidemiology and End Results data.

METHODS:

PC aIR, mortality rates, annual percentage change, and average annual percentage change (AAPC) were calculated and assessed for parallelism and identicalness. Age-specific analyses were conducted in older (≥55 years) and younger (<55 years) adults. PC incidence based on demographics, tumor characteristics, and mortality were evaluated in younger adults.

RESULTS:

A total of 454,611 patients were diagnosed with PC between 2001 and 2018 with significantly increasing aIR in women (AAPC = 1.27%) and men (AAPC = 1.14%) without a difference (P = .37). Similar results were seen in older adults. However, in younger adults (53,051 cases; 42.9% women), women experienced a greater increase in aIR than men (AAPCs = 2.36%, P < .001 vs 0.62%, P = 0.62) with nonparallel trends (P < .001) and AAPC difference of 1.74% (P < .001). This AAPC difference appears to be due to rising aIR in Blacks (2.23%; P < .001), adenocarcinoma histopathologic subtype (0.89%; P = .003), and location in the head-of-pancreas (1.64%; P < .001). PC mortality was found to be unchanged in women but decreasing in counterpart men (AAPC difference = 0.54%; P = .001).

CONCLUSION:

Using nationwide data, covering ≈64.5% of the U.S. population, we externally validate a rapidly increasing aIR of PC in younger women. There was a big separation of the incidence trend between women and men aged 15-34 years between 2001 and 2018 (>200% difference), and it did not show slowing down.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male País como asunto: America do norte Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male País como asunto: America do norte Idioma: En Año: 2023 Tipo del documento: Article