Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain.

An, Min; Qiu, Yi; Wang, Caixia; Ma, Penglei; Ding, Yumei

An, Min; Qiu, Yi; Wang, Caixia; Ma, Penglei; Ding, Yumei.

An M; Department of Anesthesiology, The Second Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China.
Qiu Y; Department of Anesthesiology, The Second Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China.
Wang C; Department of Anesthesiology, The Second Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China.
Ma P; Department of Anesthesiology, The Second Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China.
Ding Y; Department of Anesthesiology, The Second Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China.

J Neuropathol Exp Neurol ; 82(5): 419-426, 2023 04 20.

Article en En | MEDLINE | ID: mdl-36779914

Asunto(s)

Microglía; Neuralgia; Ratas; Animales; Microglía/metabolismo; Astrocitos/metabolismo; Ratas Sprague-Dawley; Sistema de Señalización de MAP Quinasas; Sirtuina 1/genética; Sirtuina 1/metabolismo; Sirtuina 1/farmacología; Constricción; Neuralgia/etiología; Neuralgia/metabolismo

Palabras clave

Apoptosis; Astrocytes; Inflammation; Microglia; Neuropathic pain; Rac2; SIRT1

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Microglía / Neuralgia Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google