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Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281.
Liu, Jinghan; Offei, Samuel D; Yoshimoto, Francis K; Scott, Emily E.
  • Liu J; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
  • Offei SD; Department of Chemistry, The University of Texas at San Antonio (UTSA), One UTSA Circle, San Antonio, Texas, USA.
  • Yoshimoto FK; Department of Chemistry, The University of Texas at San Antonio (UTSA), One UTSA Circle, San Antonio, Texas, USA.
  • Scott EE; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA; Department of Pharmacology, Biological Chemistry and Programs in Chemical Biology and Biophysics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: scottee@umich.edu.
J Biol Chem ; 299(4): 103032, 2023 04.
Article en En | MEDLINE | ID: mdl-36806682
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esteroide 12-alfa-Hidroxilasa / Diabetes Mellitus Tipo 2 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esteroide 12-alfa-Hidroxilasa / Diabetes Mellitus Tipo 2 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article