Lymphomatosis cerebri with coexistent anti-N-methyl-D-aspartate receptor antibody: A case report.
Neuropathology
; 43(5): 403-407, 2023 Oct.
Article
en En
| MEDLINE
| ID: mdl-36811198
ABSTRACT
Diagnosis of lymphomatosis cerebri (LC) is usually delayed because of its rarity and the need for pathological confirmation. The association of LC with humoral immunity has scarcely been reported. Herein, we present a woman with a 2-week history of dizziness and gait ataxia, followed by diplopia, altered mental status, and spasticity of all limbs. Magnetic resonance imaging (MRI) of the brain showed multifocal lesions involving bilateral subcortical white matter, deep gray structures, and brainstem. Oligoclonal bands and anti-N-methyl-D-aspartate receptor (NMDAR) antibodies were present in cerebrospinal fluid (CSF) twice. She was initially treated with methylprednisolone but still worsening. A stereotactic brain biopsy confirmed the diagnosis of LC. This is a report on the distinctive coexistence of the rare CNS lymphoma variant and the anti-NMDAR antibody.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Sistema Nervioso Central
/
Encefalitis Antirreceptor N-Metil-D-Aspartato
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article