Peripheral Inflammation Links with the Severity of Clinical Phenotype in Spinocerebellar Ataxia 2.
Mov Disord
; 38(5): 880-885, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-36811296
ABSTRACT
BACKGROUND:
The role of peripheral inflammation in spinocerebellar ataxia type 2 (SCA2) is unknown.OBJECTIVE:
The objective of this study was to identify peripheral inflammation biomarkers and their relationship with the clinical and molecular features.METHODS:
Blood cell count-derived inflammatory indices were measured in 39 SCA2 subjects and their matched controls. Clinical scores of ataxia, nonataxia, and cognitive dysfunction were assessed.RESULTS:
The neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the Systemic Inflammation Index (SII), and the Aggregate Index of Systemic Inflammation (AISI) were significantly increased in SCA2 subjects compared with controls. The increases in PLR, SII, and AISI were even observed in preclinical carriers. NLR, PLR, and SII were correlated with the Scale for the Assessment and Rating of Ataxia speech item score rather than with the total score. The NLR and SII were correlated with the nonataxia and the cognitive scores.CONCLUSIONS:
Peripheral inflammatory indices are biomarkers in SCA2, which may help to design future immunomodulatory trials and advance our understanding of the disease. © 2023 International Parkinson and Movement Disorder Society.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Ataxias Espinocerebelosas
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article