Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-<i>d</i>]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme.

Poggialini, Federica; Vagaggini, Chiara; Brai, Annalaura; Pasqualini, Claudia; Crespan, Emmanuele; Maga, Giovanni; Perini, Cecilia; Cabella, Noemi; Botta, Lorenzo; Musumeci, Francesca; Frosini, Maria; Schenone, Silvia; Dreassi, Elena

Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme.

Poggialini, Federica; Vagaggini, Chiara; Brai, Annalaura; Pasqualini, Claudia; Crespan, Emmanuele; Maga, Giovanni; Perini, Cecilia; Cabella, Noemi; Botta, Lorenzo; Musumeci, Francesca; Frosini, Maria; Schenone, Silvia; Dreassi, Elena.

Poggialini F; Department of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.
Vagaggini C; Department of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.
Brai A; Department of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.
Pasqualini C; Department of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.
Crespan E; Institute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy.
Maga G; Institute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy.
Perini C; Institute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy.
Cabella N; Institute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy.
Botta L; Department of Ecological and Biological Sciences, University of Tuscia, Via S.C. De Lellis s.n.c., 01100 Viterbo, Italy.
Musumeci F; Department of Pharmacy, University of Genoa, 16132 Genoa, Italy.
Frosini M; Department of Life Sciences, University of Siena, 53100 Siena, Italy.
Schenone S; Department of Pharmacy, University of Genoa, 16132 Genoa, Italy.
Dreassi E; Department of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.