Omentin-1 Levels and Outcomes in Incident Peritoneal Dialysis Patients.
Kidney Med
; 5(3): 100598, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-36852091
ABSTRACT
Rationale & Objective:
Omentin-1 is an adipokine with anti-inflammatory and cardioprotective properties. The objective of this study was to determine the prognostic role of plasma omentin-1 levels in incident peritoneal dialysis (PD) patients. StudyDesign:
Retrospective analysis of prospective cohort. Setting &Participants:
152 incident PD patients. Predictors Plasma omentin-1 level, adipose tissue omentin-1 messenger RNA (mRNA) expression.Outcomes:
Patient survival, technique survival, hospital admission, and duration of stay. AnalyticalApproach:
Time-to-event survival analyses; linear regression for hospitalization.Results:
The mean age was 58.4 ± 11.7 years; 102 were men, and 92 had diabetes. There was no significant correlation between plasma omentin-1 level and its adipose tissue mRNA expression. A higher plasma omentin-1 level quartile was not associated with patient survival (P = 0.92) or technique survival (P = 0.83) but had a modest correlation with a lower number of hospital admissions (P = 0.07) and shorter duration of hospital stay (P = 0.04). In adjusted models using multivariable linear regression, a higher plasma omentin-1 level quartile remained significantly associated with fewer hospital admissions (ß, -0.13; 95% CI, -0.26 to -0.002; P = 0.05) and shorter hospitalization duration (ß, -0.20; 95% CI, -0.38 to -0.02; P = 0.03).Limitations:
Observational study with baseline measures only.Conclusions:
Plasma omentin-1 level was not associated with patient survival, technique survival, or peritonitis, but higher plasma omentin-1 levels were associated with fewer hospital admissions and shorter duration of hospitalization among incident PD patients.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Idioma:
En
Año:
2023
Tipo del documento:
Article