Inferring protein fitness landscapes from laboratory evolution experiments.

D'Costa, Sameer; Hinds, Emily C; Freschlin, Chase R; Song, Hyebin; Romero, Philip A

D'Costa, Sameer; Hinds, Emily C; Freschlin, Chase R; Song, Hyebin; Romero, Philip A.

D'Costa S; Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America.
Hinds EC; Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America.
Freschlin CR; Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America.
Song H; Department of Statistics, Pennsylvania State University, State College, Pennsylvania, United States of America.
Romero PA; Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America.

PLoS Comput Biol ; 19(3): e1010956, 2023 03.

Article en En | MEDLINE | ID: mdl-36857380

Asunto(s)

Aptitud Genética; Proteínas; Aptitud Genética/genética; Proteínas/genética; Proteínas/metabolismo; Mutación/genética; Tetrahidrofolato Deshidrogenasa/genética; Tetrahidrofolato Deshidrogenasa/metabolismo; Secuencia de Aminoácidos; Evolución Molecular; Modelos Genéticos; Epistasis Genética

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas / Aptitud Genética Idioma: En Año: 2023 Tipo del documento: Article

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PubMed Links

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas / Aptitud Genética Idioma: En Año: 2023 Tipo del documento: Article