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Inulin prebiotic reinforces host cancer immunosurveillance via ɣδ T cell activation.
Boucher, Emilie; Plazy, Caroline; Richard, Mathias L; Suau, Antonia; Mangin, Irène; Cornet, Muriel; Aldebert, Delphine; Toussaint, Bertrand; Hannani, Dalil.
  • Boucher E; Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France.
  • Plazy C; Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, CHU Grenoble Alpes, TIMC, Grenoble, France.
  • Richard ML; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.
  • Suau A; Paris Center for Microbiome Medicine, Fédération Hospitalo-Universitaire, Paris, France.
  • Mangin I; Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France.
  • Cornet M; USC Cnam-ANSES Metabiot, Conservatoire National des Arts et Métiers, Paris, France.
  • Aldebert D; USC Cnam-ANSES Metabiot, Conservatoire National des Arts et Métiers, Paris, France.
  • Toussaint B; Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, CHU Grenoble Alpes, TIMC, Grenoble, France.
  • Hannani D; Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, Grenoble, France.
Front Immunol ; 14: 1104224, 2023.
Article en En | MEDLINE | ID: mdl-36875124
ABSTRACT
The gut microbiota is now recognized as a key parameter affecting the host's anti-cancer immunosurveillance and ability to respond to immunotherapy. Therefore, optimal modulation for preventive and therapeutic purposes is very appealing. Diet is one of the most potent modulators of microbiota, and thus nutritional intervention could be exploited to improve host anti-cancer immunity. Here, we show that an inulin-enriched diet, a prebiotic known to promote immunostimulatory bacteria, triggers an enhanced Th1-polarized CD4+ and CD8+ αß T cell-mediated anti-tumor response and attenuates tumor growth in three preclinical tumor-bearing mouse models. We highlighted that the inulin-mediated anti-tumor effect relies on the activation of both intestinal and tumor-infiltrating ɣδ T cells that are indispensable for αß T cell activation and subsequent tumor growth control, in a microbiota-dependent manner. Overall, our data identified these cells as a critical immune subset, mandatory for inulin-mediated anti-tumor immunity in vivo, further supporting and rationalizing the use of such prebiotic approaches, as well as the development of immunotherapies targeting ɣδ T cells in cancer prevention and immunotherapy.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inulina / Neoplasias Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inulina / Neoplasias Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article