Crimean-Congo hemorrhagic fever: Immunopathogenesis and recent advances in the development of vaccines.
Microb Pathog
; 177: 106054, 2023 Apr.
Article
en En
| MEDLINE
| ID: mdl-36882130
ABSTRACT
Crimean-Congo hemorrhagic fever is a serious vector-borne zoonotic viral infection which leads to severe illness and fatalities in people living in endemic regions and becoming infected sporadically. Hyalomma ticks are responsible for the transmission of the virus which belongs to the family Nairoviridae. This disease spreads through ticks bite, infected tissues, or blood of viremic animals, and from infected humans to others. Serological studies also indicate the presence of the virus in various domestic and wild animals to be a risk factor for the transmission of the disease. Crimean-Congo hemorrhagic fever virus elicits many immune responses during the infection including inflammatory, innate, and adaptive immune responses. The development of an effective vaccine could be a promising method for the control and prevention of disease in endemic areas. The purpose of this review is to highlight the importance of CCHF, its mode of transmission, the interaction of the virus with the hosts and ticks, immunopathogenesis, and advances in immunization.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Garrapatas
/
Vacunas
/
Virus de la Fiebre Hemorrágica de Crimea-Congo
/
Fiebre Hemorrágica de Crimea
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article