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Estimated glomerular filtration rate in Brazilian adults with sickle cell disease: results from the REDS-III multicenter cohort study.
Belisário, André Rolim; Simões E Silva, Ana Cristina; Moura, Isabel Cristina Gomes; Carneiro-Proietti, Anna Bárbara; Sabino, Ester Cerdeira; Loureiro, Paula; Máximo, Cláudia; Flor-Park, Miriam V; Rodrigues, Daniela de Oliveira Werneck; Ozahata, Mina Cintho; Mota, Rosimere Afonso; Dinardo, Carla Luana; Kelly, Shannon; Custer, Brian.
  • Belisário AR; Centro de Tecidos Biológicos de Minas Gerais, Fundação Hemominas, Rua das Goiabeiras, 779, Lagoa Santa, MG, 33400-000, Brazil. andrebelisario@yahoo.com.br.
  • Simões E Silva AC; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. andrebelisario@yahoo.com.br.
  • Moura ICG; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Carneiro-Proietti AB; Faculdade Ciências Médicas, Belo Horizonte, MG, Brazil.
  • Sabino EC; Centro de Tecidos Biológicos de Minas Gerais, Fundação Hemominas, Rua das Goiabeiras, 779, Lagoa Santa, MG, 33400-000, Brazil.
  • Loureiro P; Faculdade de Medicina (FMUSP) and Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil.
  • Máximo C; Fundação Hemope, Recife, PE, Brazil.
  • Flor-Park MV; Universidade de Pernambuco, Recife, PE, Brazil.
  • Rodrigues DOW; , Hemorio, Rio de Janeiro, Brazil.
  • Ozahata MC; ITACI, Unidade de Onco-Hematologia, Instituto da Criança, HCFMUSP, São Paulo, Brazil.
  • Mota RA; Centro de Tecidos Biológicos de Minas Gerais, Fundação Hemominas, Rua das Goiabeiras, 779, Lagoa Santa, MG, 33400-000, Brazil.
  • Dinardo CL; Department of Computer Science - DCC, University of São Paulo, São Paulo, Brazil.
  • Kelly S; Centro de Tecidos Biológicos de Minas Gerais, Fundação Hemominas, Rua das Goiabeiras, 779, Lagoa Santa, MG, 33400-000, Brazil.
  • Custer B; Pró-Sangue, São Paulo, Brazil.
Ann Hematol ; 102(5): 1019-1027, 2023 May.
Article en En | MEDLINE | ID: mdl-36884065
Chronic kidney disease (CKD) has a significant impact on sickle cell disease (SCD) morbidity and mortality. Early identification of individuals at highest risk of developing CKD may allow therapeutic intervention to prevent worse outcomes. This study aimed to evaluate the prevalence and risk factors for reduced estimated glomerular filtration rate (eGFR) among adults with SCD in Brazil. Participants in the REDS-III multicenter SCD cohort with more severe genotypes aged ≥ 18 years with at least two serum creatinine values were analyzed. The eGFR was calculated using the Jamaica Sickle Cell Cohort Study GFR equation. The eGFR categories were defined according to the K/DOQI. Participants with eGFR ≥ 90 were compared to those with those with eGFR < 90. Among the 870 participants, 647 (74.4%) had eGFR ≥ 90, 211 (24.3%) had eGFR 60 to 89, six (0.7%) had eGFR 30 to 59, and six (0.7%) had ESRD. Male sex (OR: 37.3; 95%CI: 22.4-65.1), higher age (OR: 1.04; 95%CI: 1.02-1.06), higher diastolic blood pressure (OR: 1.03; 95%CI: 1.009-1.06), lower Hb (OR: 0.80; 95%CI: 0.68-0.93), and lower reticulocytes (OR: 0.94; 95%CI: 0.89-0.99) levels were independently associated with eGFR < 90. There was a trend towards higher odds of death in participants with eGFR < 90 (OR: 1.8; 95%CI: 0.95-3.32; p = 0.065). In turn, participants with eGFR < 60 had a 12.2 (95%CI: 2.1-96.9) times higher odds for death when compared to those with eGFR ≥ 60. In this study, eGFR < 90 was observed in one-quarter of adults. Older age, male sex, higher diastolic blood pressure, lower hemoglobin, and lower reticulocyte levels were associated with occurrence of eGFR < 90. Estimated GFR < 60 increased the risk of mortality.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Anemia de Células Falciformes Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male País como asunto: America do sul / Brasil Idioma: En Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Insuficiencia Renal Crónica / Anemia de Células Falciformes Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male País como asunto: America do sul / Brasil Idioma: En Año: 2023 Tipo del documento: Article