SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore.

Guarnieri, Joseph W; Angelin, Alessia; Murdock, Deborah G; Schaefer, Patrick; Portluri, Prasanth; Lie, Timothy; Huang, Jessica; Wallace, Douglas C

Guarnieri, Joseph W; Angelin, Alessia; Murdock, Deborah G; Schaefer, Patrick; Portluri, Prasanth; Lie, Timothy; Huang, Jessica; Wallace, Douglas C.

Guarnieri JW; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Angelin A; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Murdock DG; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Schaefer P; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Portluri P; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Lie T; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Huang J; Department of biology, University of Pennsylvania, Philadelphia, PA, United States.
Wallace DC; Center for Mitochondrial and Epigenomic Medicine, Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Front Immunol ; 14: 1064293, 2023.

Article en En | MEDLINE | ID: mdl-36891303

Asunto(s)

COVID-19; Inflamasomas; Humanos; Inflamasomas/genética; Inflamasomas/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/genética; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Proteínas Viroporinas; SARS-CoV-2/genética; Poro de Transición de la Permeabilidad Mitocondrial; ADN Mitocondrial/metabolismo

Palabras clave

COVID-19; NLRP3-inflammasome; mitochondria in innate immune responses; mitochondrial permeability transition pore; viroporin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inflamasomas / COVID-19 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inflamasomas / COVID-19 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article