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Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation.
Kotsakis Ruehlmann, Anna; Sammallahti, Sara; Cortés Hidalgo, Andrea P; Bakulski, Kelly M; Binder, Elisabeth B; Campbell, Megan Loraine; Caramaschi, Doretta; Cecil, Charlotte A M; Colicino, Elena; Cruceanu, Cristiana; Czamara, Darina; Dieckmann, Linda; Dou, John; Felix, Janine F; Frank, Josef; Håberg, Siri E; Herberth, Gunda; Hoang, Thanh T; Houtepen, Lotte C; Hüls, Anke; Koen, Nastassja; London, Stephanie J; Magnus, Maria C; Mancano, Giulia; Mulder, Rosa H; Page, Christian M; Räikkönen, Katri; Röder, Stefan; Schmidt, Rebecca J; Send, Tabea S; Sharp, Gemma; Stein, Dan J; Streit, Fabian; Tuhkanen, Johanna; Witt, Stephanie H; Zar, Heather J; Zenclussen, Ana C; Zhang, Yining; Zillich, Lea; Wright, Rosalind; Lahti, Jari; Brunst, Kelly J.
  • Kotsakis Ruehlmann A; University of Cincinnati College of Medicine, Department of Environmental and Public Health Sciences, Cincinnati, OH, USA.
  • Sammallahti S; Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.
  • Cortés Hidalgo AP; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  • Bakulski KM; Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Binder EB; Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.
  • Campbell ML; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  • Caramaschi D; University of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI, USA.
  • Cecil CAM; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Colicino E; University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa.
  • Cruceanu C; School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
  • Czamara D; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
  • Dieckmann L; Erasmus MC, University Medical Center Rotterdam, Department of Adolescent and Child Psychiatry and Psychology, Rotterdam, Netherlands.
  • Dou J; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  • Felix JF; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Frank J; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Håberg SE; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Herberth G; Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Hoang TT; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
  • Houtepen LC; University of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI, USA.
  • Hüls A; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  • Koen N; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • London SJ; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Magnus MC; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
  • Mancano G; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
  • Mulder RH; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, USA.
  • Page CM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
  • Räikkönen K; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Röder S; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Schmidt RJ; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; and UCT Neuroscience Institute, Cape Town, South Africa.
  • Send TS; South African Medical Research Council (SAMRC) Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa.
  • Sharp G; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, USA.
  • Stein DJ; Norwegian Institute of Public Health, Centre for Fertility and Health, Oslo, Norway.
  • Streit F; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
  • Tuhkanen J; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  • Witt SH; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Zar HJ; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
  • Zenclussen AC; Department of Mathematics, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.
  • Zhang Y; University of Helsinki, Faculty of Medicine, Department of Psychology and Logopedics, Helsinki, Finland.
  • Zillich L; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany.
  • Wright R; University of California-Davis, School of Medicine, Department of Public Health Sciences, Davis, CA, USA.
  • Lahti J; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Brunst KJ; School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Mol Psychiatry ; 2023 Mar 10.
Article en En | MEDLINE | ID: mdl-36899042
ABSTRACT
Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biological mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysis included twelve non-overlapping cohorts from ten independent longitudinal studies (N = 5,496) within the international Pregnancy and Childhood Epigenetics consortium to examine maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of cg26579032 in ALKBH3. Stressor-specific domains of conflict with family/friends, abuse (physical, sexual, and emotional), and death of a close friend/relative were also associated with differential methylation of CpGs in APTX, MyD88, and both UHRF1 and SDCCAG8, respectively; these genes are implicated in neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. Thus, differences in DNA methylation at these loci may provide novel insights into potential mechanisms of neurodevelopment in offspring.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Año: 2023 Tipo del documento: Article