The Capsule Increases Susceptibility to Last-Resort Polymyxins, but Not to Other Antibiotics, in Klebsiella pneumoniae.
Antimicrob Agents Chemother
; 67(4): e0012723, 2023 04 18.
Article
en En
| MEDLINE
| ID: mdl-36912665
ABSTRACT
The extracellular capsule is a virulence factor present in many facultative pathogens, but its role in antimicrobial resistance remains controversial. To shed light on this debate, we tested six antibiotics on four Klebsiella pneumoniae species complex strains. Noncapsulated strains exhibited increased tolerance to polymyxins, but not to other antibiotics, as measured using the MIC. Our results urge caution on the use of therapeutic agents that target the capsule and may result in selection for its inactivation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Klebsiella
/
Antibacterianos
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article