Clinical characteristics, treatment, and survival of 30 patients with gastrointestinal natural killer/T-cell lymphoma.
Cancer Rep (Hoboken)
; 6(5): e1800, 2023 05.
Article
en En
| MEDLINE
| ID: mdl-36919649
ABSTRACT
BACKGROUND:
The gastrointestinal (GI) tract is the second most frequent extranasal involvement site for ENKTL. This study aimed to explore the clinicopathological features, treatment models, survival outcomes, and prognosis of gastrointestinal ENKTL (GI-ENKTL).METHODS:
The clinical data of GI-ENKTL patients were extracted from the China Lymphoma Collaborative Group (CLCG) database and were analyzed retrospectively.RESULTS:
A total of 30 patients were enrolled, with a male/female ratio of 41 and a median age of 42 years. Twenty-nine patients received chemotherapy, of whom 15 patients received asparaginase-based (ASP-based) regimens. Moreover, seven received surgery and three received radiotherapy. The overall response an d complete remission rates were 50.0% and 30.0% for the whole cohort, 50.0% and 37.5% for patients treated with ASP-based regimens, and 50.0% and 25.0% for those treated with non-ASP-based regimens, respectively. The median follow-up was 12.9 months and the 1-year overall survival rate was 40.0% for the whole cohort. For those patients in an early stage, ASP-based regimens resulted in a superior 1-year progression-free survival rate compared to non-ASP-based regimens (100.0% vs. 36.0%, p = .07). However, ASP-based regimens did not improve survival in patients at an advanced stage.CONCLUSION:
GI-ENKTL still has a poor prognosis, even in the era of modern asparaginase-based treatment strategies.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfoma Extranodal de Células NK-T
/
Neoplasias Gastrointestinales
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2023
Tipo del documento:
Article