Succinate Dehydrogenase Mutations as Familial Pheochromocytoma Syndromes.
Surg Oncol Clin N Am
; 32(2): 289-301, 2023 04.
Article
en En
| MEDLINE
| ID: mdl-36925186
ABSTRACT
It is recognized that a large portion of pheochromocytoma and paraganglioma cases will have an underlying germline mutation, supporting the recommendation for universal genetic testing in all patients with PPGLs. A mutation in succinate dehydrogenase subunit B is associated with increased rates of developing synchronous and/or metachronous metastatic disease. Patients identified with this mutation require meticulous preoperative evaluation, a personalized surgical plan to minimize the risk of recurrence and tumor spread, and lifelong surveillance.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Paraganglioma
/
Feocromocitoma
/
Succinato Deshidrogenasa
/
Neoplasias de las Glándulas Suprarrenales
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article