Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron.

Kreye, Jakob; Reincke, S Momsen; Edelburg, Stefan; Jeworowski, Lara M; Kornau, Hans-Christian; Trimpert, Jakob; Hombach, Peter; Halbe, Sophia; Nölle, Volker; Meyer, Martin; Kattenbach, Stefanie; Sánchez-Sendin, Elisa; Schmidt, Marie L; Schwarz, Tatjana; Rose, Ruben; Krumbholz, Andi; Merz, Sophie; Adler, Julia M; Eschke, Kathrin; Abdelgawad, Azza; Schmitz, Dietmar; Sander, Leif E; Janssen, Uwe; Corman, Victor M; Prüss, Harald

Kreye, Jakob; Reincke, S Momsen; Edelburg, Stefan; Jeworowski, Lara M; Kornau, Hans-Christian; Trimpert, Jakob; Hombach, Peter; Halbe, Sophia; Nölle, Volker; Meyer, Martin; Kattenbach, Stefanie; Sánchez-Sendin, Elisa; Schmidt, Marie L; Schwarz, Tatjana; Rose, Ruben; Krumbholz, Andi; Merz, Sophie; Adler, Julia M; Eschke, Kathrin; Abdelgawad, Azza; Schmitz, Dietmar; Sander, Leif E; Janssen, Uwe; Corman, Victor M; Prüss, Harald.

Kreye J; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Reincke SM; Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.
Edelburg S; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Jeworowski LM; Department of Pediatric Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Kornau HC; Berlin Institute of Health at Charité, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Trimpert J; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Hombach P; Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.
Halbe S; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Nölle V; Berlin Institute of Health at Charité, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Meyer M; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.
Kattenbach S; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Sánchez-Sendin E; German Centre for Infection Research (DZIF), 10117 Berlin, Germany.
Schmidt ML; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Schwarz T; Neuroscience Research Center (NWFZ), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Rose R; Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany.
Krumbholz A; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.
Merz S; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.
Adler JM; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.
Eschke K; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.
Abdelgawad A; Miltenyi Biotec B.V. & Co. KG, 51429 Bergisch Gladbach, Germany.
Schmitz D; German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany.
Sander LE; Helmholtz Innovation Lab BaoBab (Brain Antibody-omics and B-cell Lab), 10117 Berlin, Germany.
Janssen U; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Corman VM; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Prüss H; German Centre for Infection Research (DZIF), 10117 Berlin, Germany.