Systems metabolic engineering upgrades Corynebacterium glutamicum for selective high-level production of the chiral drug precursor and cell-protective extremolyte L-pipecolic acid.

Pauli, Sarah; Kohlstedt, Michael; Lamber, Jessica; Weiland, Fabia; Becker, Judith; Wittmann, Christoph

Pauli, Sarah; Kohlstedt, Michael; Lamber, Jessica; Weiland, Fabia; Becker, Judith; Wittmann, Christoph.

Pauli S; Institute for Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Kohlstedt M; Institute for Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Lamber J; Institute for Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Weiland F; Institute for Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Becker J; Institute for Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Wittmann C; Institute for Systems Biotechnology, Saarland University, Saarbrücken, Germany. Electronic address: christoph.wittmann@uni-saarland.de.

Metab Eng ; 77: 100-117, 2023 05.

Article en En | MEDLINE | ID: mdl-36931556

Asunto(s)

Corynebacterium glutamicum; Profármacos; Ingeniería Metabólica; Corynebacterium glutamicum/metabolismo; Profármacos/metabolismo; Lisina/genética; Oxidorreductasas/metabolismo; Glucosa/genética; Glucosa/metabolismo; Fermentación

Palabras clave

Chemical priming agent; Drug precursor; Extremolyte; GRAS; Metabolome; NAD; NADH; NADP; NADPH; Redox metabolism; Sustainable production; Transcriptome; l-Lysine; l-Pipecolic acid; l-lysine 6-Aminotransferase; l-lysine 6-Dehydrogenase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Corynebacterium glutamicum Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Corynebacterium glutamicum Idioma: En Año: 2023 Tipo del documento: Article