Your browser doesn't support javascript.
loading
Prevalence of malaria-helminth co-infections among children living in a setting of high coverage of standard interventions for malaria and helminths: Two population-based studies in Senegal.
Afolabi, Muhammed O; Sow, Doudou; Mbaye, Ibrahima; Diouf, Marie Pierre; Loum, Mor Absa; Fall, Elhadji Babacar; Seck, Amadou; Manga, Isaac A; Cissé, Cheikh; Camara, Baba; Diouf, Awa; Gaye, Ndéye Aida; Colle Lo, Aminata; Greenwood, Brian; Ndiaye, Jean Louis A.
  • Afolabi MO; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Sow D; Service de Parasitologie-Mycologie, Université Gaston Berger de Saint-Louis, Saint-Louis, Senegal.
  • Mbaye I; Service de Parasitologie-Mycologie, Université de Thies, Thies, Senegal.
  • Diouf MP; Service de Parasitologie-Mycologie, Université de Thies, Thies, Senegal.
  • Loum MA; Service de Parasitologie-Mycologie, Université Cheikh Anta Diop, Dakar, Senegal.
  • Fall EB; Service de Parasitologie-Mycologie, Université Cheikh Anta Diop, Dakar, Senegal.
  • Seck A; Service de Parasitologie-Mycologie, Université de Thies, Thies, Senegal.
  • Manga IA; Service de Parasitologie-Mycologie, Université Cheikh Anta Diop, Dakar, Senegal.
  • Cissé C; Service de Parasitologie-Mycologie, Université de Thies, Thies, Senegal.
  • Camara B; Saraya Health Centre, Saraya, Senegal.
  • Diouf A; Service de Parasitologie-Mycologie, Université de Thies, Thies, Senegal.
  • Gaye NA; Service de Parasitologie-Mycologie, Université de Thies, Thies, Senegal.
  • Colle Lo A; Service de Parasitologie-Mycologie, Université Cheikh Anta Diop, Dakar, Senegal.
  • Greenwood B; Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Ndiaye JLA; Service de Parasitologie-Mycologie, Université de Thies, Thies, Senegal.
Front Public Health ; 11: 1087044, 2023.
Article en En | MEDLINE | ID: mdl-36935683
ABSTRACT

Background:

Concurrent infections of Plasmodium falciparum with Soil Transmitted Helminths (STH) and Schistosoma spp are still a major public health problem among children living in Sub-Saharan Africa. We conducted two prospective studies among children living in urban and rural settings of Senegal, where control programmes for malaria, STH and schistosomiasis have been sustained, to determine the prevalence of malaria-helminth co-infection.

Methods:

We enrolled 910 children aged 1-14 years from Saraya and Diourbel districts of Senegal in June and November 2021, respectively. We collected finger-prick blood samples from the children for malaria parasite detection using microscopy and PCR methods. Stool samples were also collected and Kato-Katz and PCR methods were used to detect STH and S. mansoni; and Merthiolate-iodine-formalin (MIF) test for other intestinal protozoans. Urine samples were analyzed using a filtration test, Point of Care Circulating Cathodic Antigens (POC-CCA) and PCR methods for detection of S. haematobium. Statistical analyses were performed to compare the continuous and categorical variables across the two study sites and age groups, as well as using the adjusted Odds ratios (aOR) to explore risk factors for malaria-helminth co-infections.

Results:

The overall prevalence of polyparasitism with P. falciparum, STH, S. haematobium and S. mansoni among children in the two study sites was 2.2% (20/910) while prevalence of P. falciparum-S. haematobium co-infection was 1.1% (10/910); P. falciparum-S. mansoni 0.7% (6/910) and P. falciparum with any intestinal protozoan 2.4% (22/910). Co-infection was slightly higher among 5-14 year old children (17/629, 2.7%; 95% CI 1.43-3.97) than 1-4 years (3/281, 1.1%; 95% CI -0.12-2.32) and, in boys (13/567, 2.3%; 95% CI 1.27-3.96) than girls (7/343, 2.1%; 95% CI 0.52-3.48). Children aged 5-14 years (aOR = 3.37; 95% CI 0.82-13.77, p = 0.09), who were boys (aOR = 1.44; 95% CI 0.48-4.36, p = 0.51) and lived in Saraya (aOR = 1.27; 95% CI 0.24-6.69, p = 0.77) had a higher risk of malaria-helminth co-infection than other age group, in girls and those who lived in Diourbel. Living in houses with spaces between the walls and roofs as well as frequent contacts with water during swimming were statistically significant risk factors for malaria-helminth co-infection.

Conclusions:

The prevalence of malaria-helminth co-infection is low in two districts in Senegal, possibly due to sustained implementation of effective control measures for malaria and NTDs. These findings could help to develop and implement strategies that would lead to elimination of malaria and helminths in the study areas.
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Malaria Falciparum / Coinfección / Helmintiasis / Helmintos / Malaria Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male País como asunto: Africa Idioma: En Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Malaria Falciparum / Coinfección / Helmintiasis / Helmintos / Malaria Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Male País como asunto: Africa Idioma: En Año: 2023 Tipo del documento: Article