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Synthesis and anti-SARS-CoV-2 evaluation of lipid prodrugs of ß-D-N4-hydroxycytidine (NHC) and a 3'-fluoro-substituted analogue of NHC.
Wen, Zhao-Hui; Wang, Meng-Meng; Li, Ling-Yun; Herdewijn, Piet; Snoeck, Robert; Andrei, Graciela; Liu, Zhao-Peng; Liu, Chao.
  • Wen ZH; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
  • Wang MM; Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
  • Li LY; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
  • Herdewijn P; Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
  • Snoeck R; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
  • Andrei G; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium. Electronic address: graciela.andrei@kuleuven.be.
  • Liu ZP; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. Electronic address: liuzhaop@sdu.edu.cn.
  • Liu C; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. Electronic address: chaoliu@sdu.edu.cn.
Bioorg Chem ; 135: 106527, 2023 06.
Article en En | MEDLINE | ID: mdl-37031504
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / COVID-19 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / COVID-19 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article