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Benzo[b]naphtho[2,1-d]furans and 2-Phenylnaphthalenes from Streblus usambarensis.
Chepkirui, Carolyne; Ali Adem, Fozia; Rudenko, Anastasia; Gütlin, Yukino; Ndakala, Albert; Derese, Solomon; Orthaber, Andreas; Bourgard, Catarina; Yenesew, Abiy; Erdélyi, Máté.
  • Chepkirui C; Department of Chemistry, University of Nairobi, P.O. Box 30197, 00100 Nairobi, Kenya.
  • Ali Adem F; Department of Physical and Biological Sciences, Kabarak University, Private Bag-20157, Nakuru, Kenya.
  • Rudenko A; Department of Chemistry, University of Nairobi, P.O. Box 30197, 00100 Nairobi, Kenya.
  • Gütlin Y; Department of Chemistry and Molecular Biology, University of Gothenburg, and Centre for Antibiotic Resistance Research (CARe) at the University of Gothenburg, SE-405 30 Gothenburg, Sweden.
  • Ndakala A; Department of Chemistry and Molecular Biology, University of Gothenburg, and Centre for Antibiotic Resistance Research (CARe) at the University of Gothenburg, SE-405 30 Gothenburg, Sweden.
  • Derese S; Department of Chemistry, University of Nairobi, P.O. Box 30197, 00100 Nairobi, Kenya.
  • Orthaber A; Department of Chemistry, University of Nairobi, P.O. Box 30197, 00100 Nairobi, Kenya.
  • Bourgard C; Department of Chemistry - Ångström, Uppsala University, SE-751 20 Uppsala, Sweden.
  • Yenesew A; Department of Chemistry and Molecular Biology, University of Gothenburg, and Centre for Antibiotic Resistance Research (CARe) at the University of Gothenburg, SE-405 30 Gothenburg, Sweden.
  • Erdélyi M; Department of Chemistry, University of Nairobi, P.O. Box 30197, 00100 Nairobi, Kenya.
J Nat Prod ; 86(4): 1010-1018, 2023 04 28.
Article en En | MEDLINE | ID: mdl-37043719
ABSTRACT
Three new benzo[b]naphtho[2,1-d]furans, usambarins A-C (1-3), five new 2-phenylnaphthalenes, usambarins D-H (4-8), a new flavan (9), and a new phenyl-1-benzoxepin (10) as well as two known compounds (11 and 12) were isolated from the extract of the stem and roots of Streblus usambarensis (Moraceae). The structures were deduced using NMR spectroscopic and mass spectrometric analyses, and those of compounds 1 and 4 were confirmed by X-ray crystallography. Usambarin D (4) demonstrated moderate antibacterial activity (MIC 9.0 µM) against Bacillus subtilis, while none of the tested compounds were effective against Escherichia coli.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Moraceae / Furanos Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Moraceae / Furanos Idioma: En Año: 2023 Tipo del documento: Article