GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS.

Koehn, Olivia J; Lorimer, Ellen; Unger, Bethany; Harris, Ra'Mal; Das, Akansha S; Suazo, Kiall F; Auger, Shelby A; Distefano, Mark D; Prokop, Jeremy W; Williams, Carol L

Koehn, Olivia J; Lorimer, Ellen; Unger, Bethany; Harris, Ra'Mal; Das, Akansha S; Suazo, Kiall F; Auger, Shelby A; Distefano, Mark D; Prokop, Jeremy W; Williams, Carol L.

Koehn OJ; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Lorimer E; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Unger B; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Harris R; Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.
Das AS; Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.
Suazo KF; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.
Auger SA; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.
Distefano MD; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.
Prokop JW; Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA.
Williams CL; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address: williams@mcw.edu.

J Biol Chem ; 299(6): 104698, 2023 06.

Article en En | MEDLINE | ID: mdl-37059183

Asunto(s)

Proteínas de Unión al GTP Monoméricas; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Prenilación; Proteínas de Unión al GTP Monoméricas/metabolismo; Proteína de Unión al GTP rac1/genética; Proteína de Unión al GTP rac1/metabolismo; Prenilación de Proteína

Palabras clave

RAC1B; RAP1GDS1; Ras-related C3 botulinum toxin substrate 1 (RAC1); SmgGDS; click chemistry; nuclear transport; protein isoprenylation; proteinprotein interaction; small GTPase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al GTP Monoméricas Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al GTP Monoméricas Idioma: En Año: 2023 Tipo del documento: Article