Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis.
Open Forum Infect Dis
; 10(4): ofad159, 2023 Apr.
Article
en En
| MEDLINE
| ID: mdl-37065989
ABSTRACT
Eculizumab, a recombinant humanized monoclonal antibody (mAb), is used for the treatment of patients (both adults and children) with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. This mAb binds to complement protein 5 (C5), thereby inhibiting its cleavage. On the other hand, one of the C5 cleavage products, C5a, is a potent anaphylatoxin with proinflammatory properties, involved in antimicrobial surveillance. Administration of eculizumab has been reported to make patients more susceptible to infection by encapsulated bacteria. Here, we are reporting an adult case of disseminated infection due to the encapsulated yeast Cryptococcus neoformans following eculizumab therapy and discuss its pathogenesis.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
Idioma:
En
Año:
2023
Tipo del documento:
Article