Mid-Adulthood Cognitive Training Improves Performance in a Spatial Task but Does Not Ameliorate Hippocampal Pathology in a Mouse Model of Alzheimer's Disease.

Williams, Elizabeth; Mutlu-Smith, Menekse; Alex, Ashli; Chin, Xi Wei; Spires-Jones, Tara; Wang, Szu-Han

Williams, Elizabeth; Mutlu-Smith, Menekse; Alex, Ashli; Chin, Xi Wei; Spires-Jones, Tara; Wang, Szu-Han.

Williams E; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Mutlu-Smith M; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Alex A; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Chin XW; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Spires-Jones T; Centre for Discovery Brain Sciences, UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.
Wang SH; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.

J Alzheimers Dis ; 93(2): 683-704, 2023.

Article en En | MEDLINE | ID: mdl-37066912

Asunto(s)

Enfermedad de Alzheimer; Humanos; Ratones; Animales; Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/terapia; Enfermedad de Alzheimer/patología; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Ratones Transgénicos; Gliosis/terapia; Gliosis/patología; Entrenamiento Cognitivo; Hipocampo/patología; Modelos Animales de Enfermedad; Aprendizaje por Laberinto; Presenilina-1/genética; Presenilina-1/metabolismo; Péptidos beta-Amiloides/metabolismo; Ratones Endogámicos C57BL

Palabras clave

Aging; Alzheimer's disease; amyloid-ß; astrocytes; cognitive reserve; dementia; hippocampus

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article

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