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Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy.
Sharifi-Rad, Javad; Seidel, Veronique; Izabela, Michalak; Monserrat-Mequida, Margalida; Sureda, Antoni; Ormazabal, Valeska; Zuniga, Felipe A; Mangalpady, Shivaprasad Shetty; Pezzani, Raffaele; Ydyrys, Alibek; Tussupbekova, Gulmira; Martorell, Miquel; Calina, Daniela; Cho, William C.
  • Sharifi-Rad J; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. javad.sharifirad@gmail.com.
  • Seidel V; Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
  • Izabela M; Department of Advanced Material Technologies, Faculty of Chemistry, Wroclaw University of Science and Technology, Smoluchowskiego 25, 50-372, Wroclaw, Poland.
  • Monserrat-Mequida M; Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122, Palma, Spain.
  • Sureda A; Health Research Institute of Balearic Islands (IdISBa), 07120, Palma, Spain.
  • Ormazabal V; CIBER Fisiopatología de La Obesidad Y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
  • Zuniga FA; Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122, Palma, Spain.
  • Mangalpady SS; Health Research Institute of Balearic Islands (IdISBa), 07120, Palma, Spain.
  • Pezzani R; CIBER Fisiopatología de La Obesidad Y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
  • Ydyrys A; Department of Pharmacology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile.
  • Tussupbekova G; Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepción, Chile.
  • Martorell M; Department of Chemistry, NMAM Institute of Technology, Nitte, Karnataka, 574110, India.
  • Calina D; Phytotherapy Lab, Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Via Ospedale 105, 35128, Padova, Italy.
  • Cho WC; AIROB, Associazione Italiana Per La Ricerca Oncologica Di Base, Padova, Italy.
Cell Commun Signal ; 21(1): 89, 2023 05 01.
Article en En | MEDLINE | ID: mdl-37127651
ABSTRACT
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. Video Abstract.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias / Antineoplásicos Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias / Antineoplásicos Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article