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Synthetic dibenzylideneketones as promising anti-herpes simplex virus type 1 agents.
Oliveira, Thalita Zago; Fonseca, Dyenefer Pereira; Dos Santos, André Henrique; da Silva, Thays Rosa; Lazarin-Bidóia, Danielle; Din, Zia Ud; Filho, Benedito Prado Dias; Nakamura, Celso Vataru; Rodrigues-Filho, Edson; Ueda-Nakamura, Tania.
  • Oliveira TZ; Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil.
  • Fonseca DP; Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil.
  • Dos Santos AH; Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil.
  • da Silva TR; Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil.
  • Lazarin-Bidóia D; Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil.
  • Din ZU; Laboratory of Micromolecular Biochemistry of Microorganisms, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Filho BPD; Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil.
  • Nakamura CV; Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil.
  • Rodrigues-Filho E; Laboratory of Micromolecular Biochemistry of Microorganisms, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Ueda-Nakamura T; Department of Basic Health Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, 87020-900, Brazil. tunakamura@uem.br.
Arch Virol ; 168(5): 153, 2023 May 04.
Article en En | MEDLINE | ID: mdl-37140819
ABSTRACT
New antiviral agents for the treatment of herpes simplex virus type 1 (HSV-1) infection, which causes a highly prevalent and incurable disease, are needed. Here, we report for the first time the in vitro anti-HSV-1 activity of two dibenzylideneketone compounds DBK1 and DBK2. DBK1 demonstrated virucidal activity, and high-resolution scanning electron microscopy showed that it caused morphological changes in the HSV-1 envelope. DBK2 was able to reduce HSV-1 plaque size in vitro. The DBKs are promising anti-HSV-1 candidates, as they exhibit low toxicity and exert an antiviral effect by acting at the early stages of HSV-1-host cell interaction.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Herpesvirus Humano 1 / Herpes Simple Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Herpesvirus Humano 1 / Herpes Simple Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article