Basement membrane proteins in extracellular matrix characterize NF1 neurofibroma development and response to MEK inhibitor.

Jiang, Chunhui; Kumar, Ashwani; Yu, Ze; Shipman, Tracey; Wang, Yong; McKay, Renee M; Xing, Chao; Le, Lu Q

Jiang, Chunhui; Kumar, Ashwani; Yu, Ze; Shipman, Tracey; Wang, Yong; McKay, Renee M; Xing, Chao; Le, Lu Q.

Jiang C; Department of Dermatology.
Kumar A; Eugene McDermott Center for Human Growth and Development.
Yu Z; Eugene McDermott Center for Human Growth and Development.
Shipman T; Department of Dermatology.
Wang Y; Department of Dermatology.
McKay RM; Department of Dermatology.
Xing C; Eugene McDermott Center for Human Growth and Development.
Le LQ; Lyda Hill Department of Bioinformatics.

J Clin Invest ; 133(12)2023 06 15.

Article en En | MEDLINE | ID: mdl-37140985

Asunto(s)

Neurofibroma; Neurofibromatosis 1; Humanos; Neurofibromatosis 1/tratamiento farmacológico; Neurofibromatosis 1/genética; Neurofibromatosis 1/complicaciones; Factor de Crecimiento Transformador beta1/genética; Factor de Crecimiento Transformador beta1/metabolismo; Proteínas de la Membrana/metabolismo; Proteómica; Neurofibroma/tratamiento farmacológico; Neurofibroma/genética; Inhibidores de Proteínas Quinasas; Colágeno/metabolismo; Membrana Basal/metabolismo; Membrana Basal/patología; Matriz Extracelular/metabolismo; Quinasas de Proteína Quinasa Activadas por Mitógenos; Células de Schwann/patología

Palabras clave

Extracellular matrix; Macrophages; Oncology; Tumor suppressors

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neurofibromatosis 1 / Neurofibroma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

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