The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction.
Clin Sci (Lond)
; 137(9): 707-725, 2023 05 05.
Article
en En
| MEDLINE
| ID: mdl-37144447
ABSTRACT
Sepsis is a dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents. Gene transcription and downstream pathways are either up- or downregulated, albeit with considerable fluctuation over the course of the patient's illness. This multi-system complexity contributes to a pathophysiology that remains to be fully elucidated. Consequentially, little progress has been made to date in developing new outcome-improving therapeutics. Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance. However, little attention has been paid to an integrated view of how these hormonal changes impact upon the development of organ dysfunction and recovery. Here, we present a narrative review describing the impact of the altered endocrine system on mitochondrial dysfunction and immune suppression, two interlinked and key aspects of sepsis pathophysiology.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sepsis
/
Insuficiencia Multiorgánica
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article