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Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma.
Hong, Xuan; Hsieh, Min-Tsang; Tseng, Tzu-Yu; Lin, Hui-Yi; Chang, Hung-Chih; Yau, Sir-Theng; Cheng, Wei-Chung; Ke, Baozhen; Liao, Hsiao-Hui; Wu, Chih-Ying; Liu, An-An; Wu, Meei-Maan; Huang, Kuo-Yen; Yang, Pan-Chyr; Kuo, Sheng-Chu; Hung, Mien-Chie; Lee, Pei-Chih.
  • Hong X; Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
  • Hsieh MT; School of Pharmacy, China Medical University, Taichung, Taiwan; Research Center for Chinese Herbal Medicine, China Medical University, Taichung, Taiwan; Chinese Medicinal Research and Development Center, China Medical University Hospital, Taichung, Taiwan.
  • Tseng TY; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
  • Lin HY; Research Center for Chinese Herbal Medicine, China Medical University, Taichung, Taiwan.
  • Chang HC; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
  • Yau ST; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
  • Cheng WC; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, China Medical University, Taichung, Taiwan.
  • Ke B; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Liao HH; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
  • Wu CY; Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Liu AA; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
  • Wu MM; Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University,
  • Huang KY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Yang PC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Kuo SC; School of Pharmacy, China Medical University, Taichung, Taiwan; Research Center for Chinese Herbal Medicine, China Medical University, Taichung, Taiwan.
  • Hung MC; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. Electronic address: mhung@cmu.edu.tw.
  • Lee PC; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. Electronic address: antiolde333@gmail.com.
J Biol Chem ; 299(6): 104814, 2023 06.
Article en En | MEDLINE | ID: mdl-37178919
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Diarilheptanoides / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Diarilheptanoides / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article