Increased Cerebrospinal Fluid Levels of Soluble Triggering Receptor Expressed on Myeloid Cells 2 and Chitinase-3-Like Protein 1 in Idiopathic Normal-Pressure Hydrocephalus.
J Alzheimers Dis
; 93(4): 1341-1354, 2023.
Article
en En
| MEDLINE
| ID: mdl-37182875
ABSTRACT
BACKGROUND:
Neurodegenerative disease pathology is associated with neuroinflammation, but evidence on idiopathic normal pressure hydrocephalus (iNPH) remains limited and cerebrospinal fluid (CSF) biomarker profiles need to be elucidated.OBJECTIVE:
To investigate whether iNPH pathological mechanisms are associated with greater CSF markers of core Alzheimer's disease pathology (amyloid-ß42 (Aß42), phosphorylated tau (P-tau)), neurodegeneration (total tau (T-tau)), and neuroinflammation (soluble triggering receptor expressed on myeloid cells 2 (sTREM2), chitinase-3-like protein 1 (YKL-40)).METHODS:
The study analyzed lumbar CSF samples from 63 patients with iNPH and 20 age-matched orthopedic surgery patients who had no preoperative gait or cognitive impairment (control group). Aß42, T-tau, P-tau, sTREM2, and YKL-40 in different subgroups were investigated.RESULTS:
CSF sTREM2 levels were significantly higher in the iNPH group than in the control group, but no significant between-group difference was noted in YKL-40. Moreover, YKL-40 levels were significantly higher in the tap test non-responders than in the tap test responders (pâ=â0.021). At the 1-year follow-up after shunt surgery, the CSF P-tau levels were significantly lower (pâ=â0.020) in those with gait improvement and the CSF sTREM2 levels were significantly lower (pâ=â0.041) in those with cognitive improvement. In subgroup analysis, CSF sTREM2 levels were strongly correlated with CSF YKL-40 in the iNPH group (râ=â0.443, pâ<â0.001), especially in the tap test non-responders (râ=â0.653, pâ=â0.002).CONCLUSION:
YKL-40 and sTREM2 are disease-specific markers of neuroinflammation, showing higher CSF levels in iNPH. In addition, sTREM2 is positively associated with YKL-40, indicating that interactions of glial cells play an important role in iNPH pathogenesis.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Quitinasas
/
Enfermedades Neurodegenerativas
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Enfermedad de Alzheimer
/
Hidrocéfalo Normotenso
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article