Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment. / çå¨èå¹²ç»èä¸ççå¾®ç¯å¢ç¸äºä½ç¨ç主è¦çç©å¦æºå¶æ¦è¿°.
J Zhejiang Univ Sci B
; 24(5): 373-386, 2023 Apr 15.
Article
en En, Zh
| MEDLINE
| ID: mdl-37190887
ABSTRACT
Periodontitis is a complex chronic inflammatory disease. The invasion of pathogens induces the inflammatory microenvironment in periodontitis. Cell behavior changes in response to changes in the microenvironment, which in turn alters the local inflammatory microenvironment of the periodontium through factors secreted by cells. It has been confirmed that periodontal ligament stem cells (PDLSCs) are vital in the development of periodontal disease. Moreover, PDLSCs are the most effective cell type to be used for periodontium regeneration. This review focuses on changes in PDLSCs, their basic biological behavior, osteogenic differentiation, and drug effects caused by the inflammatory microenvironment, to provide a better understanding of the influence of these factors on periodontal tissue homeostasis. In addition, we discuss the underlying mechanism in detail behind the reciprocal responses of PDLSCs that affect the microenvironment.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ligamento Periodontal
/
Periodontitis
Límite:
Humans
Idioma:
En
/
Zh
Año:
2023
Tipo del documento:
Article