Influence of the application mode of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide on the localization of its carcinogenic expression in female NMRI-mice.
Cancer Lett
; 31(3): 311-8, 1986 Jun.
Article
en En
| MEDLINE
| ID: mdl-3719571
ABSTRACT
The administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide FANFT) by gavage to female NMRI-mice resulted in a high incidence of neoplasms of the forestomach. From 117 effective animals which were pooled from 3 dosed groups, 30 squamous cell carcinomas and 26/117 papillomas of the forestomach were diagnosed. Only 5/117 neoplasms of the urinary bladder occurred. The average cumulative dose administered was 1180 mg/mouse, and the mean latent period for the induction of forestomach tumours was 574 days. The mode of application seems to be an important factor in the carcinogenicity of FANFT.
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Banco de datos:
MEDLINE
Asunto principal:
Papiloma
/
Neoplasias Gástricas
/
Tiazoles
/
Neoplasias de la Vejiga Urinaria
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
FANFT
Límite:
Animals
Idioma:
En
Año:
1986
Tipo del documento:
Article