Pseudophosphatase STYXL1 depletion enhances glucocerebrosidase trafficking to lysosomes via ER stress.

Patel, Saloni; Bhatt, Anshul Milap; Bhansali, Priyanka; Setty, Subba Rao Gangi

Patel, Saloni; Bhatt, Anshul Milap; Bhansali, Priyanka; Setty, Subba Rao Gangi.

Patel S; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Bhatt AM; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Bhansali P; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
Setty SRG; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.

Traffic ; 24(7): 254-269, 2023 07.

Article en En | MEDLINE | ID: mdl-37198709

Asunto(s)

Proteínas Reguladoras de la Apoptosis; Enfermedad de Gaucher; Glucosilceramidasa; Humanos; Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice/metabolismo; Estrés del Retículo Endoplásmico; Enfermedad de Gaucher/metabolismo; Enfermedad de Gaucher/terapia; Glucosilceramidasa/genética; Glucosilceramidasa/metabolismo; Células HeLa; Lisosomas/metabolismo; Proteínas Reguladoras de la Apoptosis/genética

Palabras clave

ER stress and Gaucher disease; STYXL1; TFE3; TFEB; lysosome; pseudophosphatase; ß-glucocerebrosidase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Reguladoras de la Apoptosis / Enfermedad de Gaucher / Glucosilceramidasa Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

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