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The retinal neurovascular coupling is impaired in men with vasculogenic erectile dysfunction.
Borrelli, Enrico; Quarta, Alberto; Pozzi, Edoardo; Fallara, Giuseppe; Pennisi, Flavia; Casaluci, Marco; Lamanna, Francesca; Querques, Lea; Sacconi, Riccardo; Bandello, Francesco; Montorsi, Francesco; Salonia, Andrea; Querques, Giuseppe.
  • Borrelli E; Vita-Salute San Raffaele University, Via Olgettina 60, Milan, Italy.
  • Quarta A; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Pozzi E; Vita-Salute San Raffaele University, Via Olgettina 60, Milan, Italy.
  • Fallara G; Vita-Salute San Raffaele University, Via Olgettina 60, Milan, Italy.
  • Pennisi F; Division of Experimental Oncology/Unit of Urology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Casaluci M; Vita-Salute San Raffaele University, Via Olgettina 60, Milan, Italy.
  • Lamanna F; Division of Experimental Oncology/Unit of Urology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Querques L; Vita-Salute San Raffaele University, Via Olgettina 60, Milan, Italy.
  • Sacconi R; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Bandello F; Vita-Salute San Raffaele University, Via Olgettina 60, Milan, Italy.
  • Montorsi F; Vita-Salute San Raffaele University, Via Olgettina 60, Milan, Italy.
  • Salonia A; Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Querques G; Vita-Salute San Raffaele University, Via Olgettina 60, Milan, Italy.
Sci Rep ; 13(1): 8237, 2023 05 22.
Article en En | MEDLINE | ID: mdl-37217570
ABSTRACT
The aim of this study was to study the retinal vessels in patients affected by vasculogenic erectile dysfunction (ED), using dynamic vessel analyzer (DVA). Patients with vasculogenic ED and control subjects were prospectively enrolled to undergo a complete urological and ophthalmologic evaluation, including DVA and structural optical coherence tomography (OCT). The main outcome measures were (1) arterial dilation; (2) arterial constriction; (3) reaction amplitude (the difference between arterial dilation and constriction); and, (4) venous dilation. Thirty-five patients with ED and 30 male controls were included in the analysis. Mean ± SD age was 52.0 ± 10.8 years in the ED group and 48.1 ± 16.3 years in the control group (p = 0.317). In the dynamic analysis, the arterial dilation was lower in the ED group (1.88 ± 1.50%), as compared with the control group (3.70 ± 1.56%, p < 0.0001). Neither arterial constriction nor venous dilation differed between groups. The reaction amplitude was decreased in ED patients (2.40 ± 2.02%, p = 0.023), compared to controls (4.25 ± 2.20%). In the Pearson correlation analysis, the ED severity, was directly correlated with both reaction amplitude (R = .701, p = 0.004) and arterial dilation (R = .529, p = 0.042). In conclusion, subjects with vasculogenic ED are featured by a significant dysfunction of the retinal neurovascular coupling, which is inversely correlated with ED severity.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Vasculares / Acoplamiento Neurovascular / Disfunción Eréctil Límite: Adult / Humans / Male / Middle aged Idioma: En Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Vasculares / Acoplamiento Neurovascular / Disfunción Eréctil Límite: Adult / Humans / Male / Middle aged Idioma: En Año: 2023 Tipo del documento: Article