Association between cancer history and second-generation drug-eluting stent thrombosis: insights from the REAL-ST registry.
Thromb J
; 21(1): 60, 2023 May 24.
Article
en En
| MEDLINE
| ID: mdl-37226249
ABSTRACT
BACKGROUND:
Cancer-associated thrombosis is a frequent complication of cancer; however, little evidence is available regarding the association between cancer history and coronary artery stent thrombosis (ST). We aimed to investigate the relationship between cancer history and second-generation drug-eluting stent thrombosis (G2-ST).METHODS:
From the REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation Drug-Eluting Stent Implantation) registry, this study evaluated 1265 patients (G2- ST cases, n = 253; controls, n = 1012) with cancer-related information available.RESULTS:
The prevalence of patients with cancer history was higher (12.3% vs. 8.5%, p = 0.065), and that of currently diagnosed and currently treated cancer was significantly higher in ST cases than controls (3.6% vs. 1.4%, p = 0.021; 3.2% vs. 1.3%, p = 0.037, respectively). Multivariable logistic regression analysis revealed that cancer history was associated with late ST (odds ratio [OR] 2.80, 95% confidence intervals [CI] 0.92-8.55, p = 0.071) and very late ST (OR 2.40, 95% CI 1.02-5.65, p = 0.046), but not with early ST (OR 1.01, 95% CI 0.51-2.00, p = 0.97). During the median follow-up period of 872 days after the index ST events, patients with cancer history showed a higher mortality than those without, among both ST cases (hazard ratio [HR] 1.93, 95% CI 1.06-3.51, p = 0.031) and controls (HR 1.93, 95% CI 1.09-3.40, p = 0.023).CONCLUSION:
A post hoc analysis of REAL-ST registry revealed that patients with G2-ST had a higher prevalence of currently diagnosed and currently treated cancer. Notably, cancer history was associated with the occurrence of late and very late ST, but not with early ST.
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Banco de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
/
Risk_factors_studies
Idioma:
En
Año:
2023
Tipo del documento:
Article