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Structural elements that enable specificity for mutant EGFR kinase domains with next-generation small-molecule inhibitors.
Damghani, Tahereh; Wittlinger, Florian; Beyett, Tyler S; Eck, Michael J; Laufer, Stefan A; Heppner, David E.
  • Damghani T; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, United States.
  • Wittlinger F; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany.
  • Beyett TS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.
  • Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.
  • Laufer SA; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Eberhard Karls Universität Tübingen, Tübingen, Germany
  • Heppner DE; Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY, United States; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States. Electronic address: davidhep@buffalo.edu.
Methods Enzymol ; 685: 171-198, 2023.
Article en En | MEDLINE | ID: mdl-37245901
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article