Two New Cembranoids from the Chinese Soft Coral Sarcophyton boettgeri.
Chem Biodivers
; 20(7): e202300662, 2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-37254816
ABSTRACT
Two new cembranoids, namely sarcoboettgerols D and E, together with four known related ones, have been isolated from the soft coral Sarcophyton boettgeri collected from Weizhou Island in the South China Sea. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance methods, time-dependent density functional theory-electronic circular dichroism calculations, as well as comparison with the reported data in the literature. A plausible biogenetic relationship of four cembranoids was proposed. In bioassays, sarcomililatin B exhibited cytotoxic activity against H1299â
cell (IC50 =35.0â
µM), whereas sarcomililatin B and sarcomililatin A displayed moderate antibacterial activities (MIC 17.4-34.8â
µg/mL).
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antozoos
/
Diterpenos
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article