Antibody-Drug Conjugates in the Treatment of Urothelial Cancer.
BioDrugs
; 37(4): 505-520, 2023 Jul.
Article
en En
| MEDLINE
| ID: mdl-37256534
ABSTRACT
Antibody-drug conjugates (ADCs) have transformed the treatment landscape in oncology and become an essential therapeutic modality. In urothelial carcinoma (UC), the two ADCs that have been especially successful in clinical practice are enfortumab vedotin and sacituzumab govitecan. These drugs are currently approved as monotherapy for later lines of treatment in locally advanced or metastatic UC and have had a significant impact for patients with limited treatment options. Combinational trials, as well as additional ADCs, are currently being investigated in the treatment of UC for subsequent lines of therapy as overall survival rates remain dismal.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Carcinoma de Células Transicionales
/
Inmunoconjugados
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article