Immunohistochemical Analysis of Lung Adenocarcinoma in Russian Mayak Nuclear Workers.
Cancer Invest
; 41(7): 686-698, 2023 Sep.
Article
en En
| MEDLINE
| ID: mdl-37291892
ABSTRACT
Specimens of lung adenocarcinoma (AdCa) from Russian nuclear workers (n = 54) exposed to alpha particles and gamma rays and from individuals non-exposed to radiation (n = 21) were examined using immunohistochemistry. Estimated significant associations with alpha dose were negative for Ki-67 and collagen IV in AdCa. Associations with gamma-ray dose were negative for tissue inhibitor of matrix metalloproteinase 2 and caspase 3 and positive for matrix metalloproteinase 2 and leukemia inhibiting factor in AdCa. The findings provide some evidence supporting alterations in apoptosis, cell proliferation and extracellular matrix in lung tissues affected by chronic radiation exposure that can contribute to radiogenic cancerogenesis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
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Exposición a la Radiación
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Adenocarcinoma del Pulmón
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Neoplasias Pulmonares
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article