A novel combination therapy of arginine deiminase and an arginase inhibitor targeting arginine metabolism in the tumor and immune microenvironment.

Ye, Pei-Hsuan; Li, Chung-Yen; Cheng, Hao-Yu; Anuraga, Gangga; Wang, Chih-Yang; Chen, Feng-Wei; Yang, Shiang-Jie; Lee, Kuo-Ting; Chang, Kwang-Yu; Lai, Ming-Derg

Ye, Pei-Hsuan; Li, Chung-Yen; Cheng, Hao-Yu; Anuraga, Gangga; Wang, Chih-Yang; Chen, Feng-Wei; Yang, Shiang-Jie; Lee, Kuo-Ting; Chang, Kwang-Yu; Lai, Ming-Derg.

Ye PH; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University Tainan, Taiwan, ROC.
Li CY; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University Tainan, Taiwan, ROC.
Cheng HY; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University Tainan, Taiwan, ROC.
Anuraga G; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica Taipei, Taiwan, ROC.
Wang CY; Department of Biological Science, Faculty of Science and Technology, Universitas PGRI Adi Buana Surabaya 60234, Indonesia.
Chen FW; PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica Taipei, Taiwan, ROC.
Yang SJ; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University Tainan, Taiwan, ROC.
Lee KT; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University Tainan, Taiwan, ROC.
Chang KY; Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan, Taiwan, ROC.
Lai MD; National Institute of Cancer Research, National Health Research Institutes Tainan, Taiwan, ROC.